Centrifuge experiments were conducted on Berea cores to measure the drainage and imbibition relative permeabilities in two- and three-phase systems. Three crude oils, Prudhoe Bay and Shell Mars A-1 and A-20 crude were used in our tests. No effect on oil recovery was obtained in the drainage experiments when the crude oil was displaced by air at connate water. However, in the imbibition experiments the oil recovery increased significantly with the salinity of the connate brine. The salinity of the displacing brine had no significant influence on the oil recovery. The relative permeability curves obtained during drainage were also found to be insensitive to the salinity of the brine. However, the imbibition relative permeability curves show strong salinity dependence. A comparison of the two crude oils and a nonpolar mineral oil indicates that the more water-wetting Mars crude oil shows a higher oil relative permeability at the same bond number compared to the mixed-wetting Prudhoe Bay crude oil. The salinity dependence of the residual saturations and the relative permeabilities clearly indicate that the change in wetting properties of the rocks surfaces from water-wet to mixed-wet during the drainage process is an important factor controlling the imbibition relative permeability curves. This suggests that the performance of waterfloods will be strongly affected by the composition of the crude oil and its ability to wet the rock surfaces, the salinity of the connate brine in the reservoir, and the height above the oil/water contact.